In recent years a lot of scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery. Various advances are presently employed in the prolongation of the gastric retention time, including floating drug delivery systems (FDDS). Polymeric floating microspheres can be employed to deliver medication at a rate-controlled and sometimes targeted manner. In this review, the challenges and limitations in the developments of FDDS of microspheres for oral controlled drug delivery are discussed. This review also highlights the Physiological challenges like fluids in the abdomen for the drug delivery buoy to float therein and to operate efficiently, drugs which don’t have solubility or stability problems in gastric fluids. Formulation challenges like formation of droplet, stirring speed and stirring time. Selection of drug concentration, polymer concentration, is one of the important challenges because it affects on particle size, drug encapsulation efficiency and drug release characteristics. Another some important challenges related to formulation technique, preparation methods of microspheres and Real life challenges in the microsphere as floating drug delivery were also discussed.
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